RHOFADE® cream reduced persistent facial redness due to rosacea in adults all day, through 12 hours on day 29.1

Before and Afters


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RHOFADE® (oxymetazoline hydrochloride) CREAM, 1% is a prescription medicine used on the skin (topical) to treat facial redness due to rosacea that does not go away (persistent) in adults.


Before you use RHOFADE® Cream, tell your healthcare provider about all of your medical conditions, including if you: have heart, blood vessel, or blood pressure problems, or narrow-angle glaucoma (call your healthcare provider or get medical help if these conditions worsen); have problems with blood circulation or have had a stroke; have Sjӧgren’s syndrome; have scleroderma; have Raynaud’s phenomenon; have thromboangiitis obliterans; have irritated skin or open sores on the face; are pregnant or plan to become pregnant; or are breastfeeding. It is not known if RHOFADE® Cream will harm your unborn baby. It is not known if RHOFADE® Cream passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use RHOFADE® Cream.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, skin products, vitamins, and herbal supplements. Using RHOFADE® Cream with certain other medicines may affect each other and can cause serious side effects.

The most common side effects of RHOFADE® Cream include application-site reactions of: skin reactions (dermatitis), worsening of rosacea pimples, itching, redness, and pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for the RHOFADE® Cream full Product Information.